Doxazosin is a hypotensive product for the treatment of the arterial hypertension, a selective blocker of alpha1-adrenergic receptors which are located in the blood vessels, prostatic gland, and urinary tract. Doxazosin is an adrenergic blocking agent of the second generation, and therefore it has a long-term action without side effects.
The effect of the reduction of the blood pressure during the use of Doxazosin happens by means of the relaxation of the smooth muscle fibers in the blood vessels. As a result, the walls of the blood vessels are dilated, the blood flow is improved, and the blood pressure drops. Doxazosin blocks the adrenoreceptors of arteries and veins, and this causes a reduction of the vascular resistance and a gradual regulation of the pressure.
After one-time use of the therapeutic dose of Doxazosin, a hypotensive effect develops in 4-6 hours but it is kept within 24 hours. A stable therapeutic effect is observed in 10-14 days.
Doxazosin is ineffective during the inhibition of the hypertonic crisis. This medicine is used in the background therapy of the arterial hypertension for a long-term control of the blood pressure.
In what dose is Doxazosin used?
Doxazosin in tablets is used once per day in the morning or evening. The medicine is better digested during the use on an empty stomach. After the first use of Doxazosin, an evident pharmacological action is observed, and therefore the treatment should be started from a low dose. A started therapeutic dose of Doxazosin is 2 mg per day.
To increase a hypotensive action, a dose of Doxazosin is gradually increased. The optimal working dose of Doxazosin is 4-8 mg per day, and the maximal one is 16 mg.
In case of a low reaction to the treatment, the therapy is increased by means of the use of thiazide diuretics or ACE inhibitors. A combined treatment should be controlled by cardiologist.
- Doxazosin should be carefully used during impairments of liver, kidneys, and mitral stenosis
- Pregnant women may take Doxazosin only by doctor’s recommendation and in the minimal dose of 2-4 mg
- Doxazosin is not prescribed children under 16 years old
- If hypotension, the use of Doxazosin is contraindicated
- Antibiotics, indirect anticoagulants, hypoglycemic products do not influence on the therapeutic functions of Doxazosin
- Alcohol consumption is not recommended during the use of Doxazosin
A phenomenon of the “first dose” may be accompanied by the side effects: postural hypotension, dizziness, faintness, headache, fatigue, and tachycardia. These side effects usually pass in several days after the use of the tablets. They maximally last for 1-2 weeks, and then they pass without a medical aid.
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